The matchday 27 Serie A clash between Internazionale and Genoa is set to take place on 28 February at 22:45 at San Siro. Internazionale vs Genoa: prediction, betting odds and statistics.
Internazionale
The home team secured a confident 2:0 win over Lecce last round, extending their impressive run to seven consecutive Serie A victories. After 26 matches, the side are firmly top of the standings with 64 points, sitting 10 points clear of their closest challenger. Internazionale are showing not only a potent attack, leading the league for goals scored with an average of 2.4 goals per game, but also a solid defence, ranking among the top four teams by that metric. With such an all-round display, Cristian Chivu's men are proving they are the leading contenders for the title this season.
- The club have scored at least twice in five previous Serie A matches.
- The team are unbeaten in six straight home league games (five wins, one draw).
- In five of Internazionale's last seven matches in this tournament, at least one team failed to score.
Potential Internazionale Lineup (3-5-2)*
Yann Sommer – Yann Bisseck, Manuel Akanji, Alessandro Bastoni – Luis Henrique, Nicolo Barella, Piotr Zielinski, Petar Sucic, Federico Dimarco – Lautaro Martinez, Marcus Thuram
Midfielder Denzel Dumfries and forward Lautaro Martinez will be sidelined through injury. Midfielders Hakan Calhanoglu and Nicolo Barella are suspended.
Genoa
The away side, as in previous seasons, are hovering in the lower part of the table – the relegation zone is still on the horizon, although the situation is gradually improving. After 26 rounds, Genoa have established themselves in 14th place with 27 points. For now, that return allows the team to look ahead with optimism about securing their Serie A status. In their most recent match, Daniele De Rossi's men had no trouble dealing with their neighbours Torino, beating their opponents 3:0. Particularly striking is the upturn in scoring at their home ground. Across their last five home matches, Genoa have hit 12 goals past opponents – a figure uncharacteristic for a team known for traditionally cautious tactics. And in general, the overall numbers for the season confirm the Genoese club have started to play with more threat. Their average expected goals (xG) is 1.21 per match.
- Across their last seven away league games, Genoa have recorded just one win (four draws, two defeats).
- In five of the club's last seven Serie A head-to-heads, at least three goals were scored.
- The Genoese side have failed to score in only two away matches this season.
Potential Genoa Lineup (3-5-2)*
Justin Beilo – Alessandro Marcandalli, Leo Ostigard, Joan Vasquez – Brooke Norton-Cuffy, Ruslan Malinovskyi, Morten Frendrup, Mikael Ellertsson, Junior Messias – Vitinha, Lorenzo Colombo.
Referee
Michael Fabbri (Italy)
Matches – 9 (Serie A, 2025/26);
Yellow cards shown (including second yellows) – 39;
Average yellow cards per match – 4.3;
Red cards shown – 2;
Average fouls per match – 26;
Penalties – 33%.
Internazionale vs Genoa: Match Prediction
Historically, Internazionale have not been the most comfortable opponent for Genoa, and in the 21st century the Genoese side have not managed to beat them even once. However, there are a few nuances in the upcoming match that could add some intrigue. Internazionale are, of course, the favourites and are fighting for the title. But the fatigue factor after Champions League matches is a serious argument. A packed schedule, with the Coppa Italia also coming after Genoa, could force the coaching staff to consider rotating the squad, which sometimes reduces cohesion.
The away team, meanwhile, really have been playing bright, attacking football this season under De Rossi. It is worth noting that the club have failed to score in only two away matches in the 2025/26 season, while Genoa have found the net against Como, Milan and Roma, with the latter boasting the most reliable defence in the league at the moment. The team are not afraid to take the initiative and create chances. For them, this match is a great opportunity to make a statement against one of the giants.
The match could turn out to be more tense and even than the teams' positions suggest. Although Internazionale clearly have a class advantage, Genoa have a chance to seize the moment and, if not win, then at least put up serious resistance. And the Milan side's defence faces a tough test: the Genoese team have scored at least twice in four of their last five Serie A matches.
Prediction: Over 2.5 goals
* For each team, the starting XI from their previous match in this tournament is listed.